Brcatwohithypothesis

Thus, in order for a particular cell to become cancerous, both of the cell's tumor suppressor genes must be mutated. This idea is known as the two-hit ...

由 JP Issa 著作 · 2022 · 被引用 13 次 — Knudson formulated the two-hit hypothesis to explain familial versus sporadic cancer epidemiology, proposing that the same genes are involved in ...

由 MD Iniesta 著作 · 2010 · 被引用 7 次 — According to the two-hit hypothesis, individuals carrying a germ-line mutation in one copy of either BRCA gene would require just one additional ...

由 N Premnath 著作 · 2020 · 被引用 7 次 — BRCA genes follow Knudson's two hit hypothesis where the second hit in the wild type allele of a germline mutation carrier is accrued by loss of allele or ...

The Knudson hypothesis, also known as the two-hit hypothesis, is the hypothesis that most tumor suppressor genes require both alleles to be inactivated, ...

由 AG Knudson 著作 · 1996 · 被引用 648 次 — According to a “two-hit” model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a secon.

由 F Meric-Bernstam 著作 · 2007 · 被引用 25 次 — Heterogenic loss of BRCA in breast cancer: the two-hit hypothesis takes a hit.

The two-hit hypothesis provided a unifying model for understanding cancer that occurs in individuals who carry a susceptibility gene and cancers that ...

由 D Stoppa-Lyonnet 著作 · 2016 · 被引用 122 次 — Tumourigenesis in germline BRCA1/2 pathogenic mutation carriers generally follows a two-hit hypothesis, the first 'hit' owing to the ...